SKIPER学院（海外）名师讲堂第二十七讲暨海外人才走进科学院活动系列讲座

报告人：余迪博士 澳大利亚莫纳什大学分子免疫调理研究室主任

报告题目：Regulating antibody response by follicular helper T cells

报告时间：2013年6月20日 （周四）下午14:00-16:00

报告地点：生化工程科研楼一层会议室

主持人：马光辉研究员

报告摘要：

CD4 T cells play a central role in regulating the immune system. Regulatory functions of CD4 T cells are specified by their commitment into different subsets, including Th1, Th2, Th17, Tfh and Treg cells as major subsets. We are studying a newly identified specialised helper T cell subset, termed follicular helper T (Tfh) cells, which is essential to regulate the high-affinity and long term antibody responses. Antibodies are the basis of most successful vaccinations. Diminished antibody responses lead to immunodeficiency while excessive antibody responses contribute to autoimmune diseases. In last few years, we have identified the key transcription factor Bcl6 directing the differentiation of Tfh cells and demonstrated excessive Tfh cells promoting autoimmunity using animal models. Understanding CD4 T cell subsets pave the way for immunomonitoring and immunomodulation in disease diagnosis and treatment.