张松平，研究员，博士生导师，课题组长，中国科学院过程工程研究所生物医药研究部主任。先后于1998年和2002年获得天津大学学士和博士学位。博士论文曾荣获“全国百篇优秀博士论文提名奖”。2002-2004年瑞典Lund大学博士后，2005年1月加入中科院过程所生化工程国家重点实验室。研究方向是生物医药工程，近期重点以mRNA、蛋白质药物、重组病毒样颗粒/病毒载体等生物大分子药物为研究对象，聚集其制备和应用过程中的结构稳定和活性保持，开展分子设计、精准合成、抗失活纯化与组装、以及新型递送系统的研究，以此发展生物大分子药物先进制备过程和理论。

目前已在生物催化、生物分离、生物药制剂等领域发表论文150余篇，申请发明专利40余项，多项成果获得实施应用。建立的灭活口蹄疫病毒抗原含量快速、定量检测技术，被国家农业部推荐为试行检测标准在疫苗生产企业应用。兼任国家农业部兽药评审专家，CDE特别聘请的疫苗评审咨询专家，《J Chromatography A》、《Biochemical Engineering J》和《Biotech Notes》编委。

1. Lin Xuan, Su Zhiguo, Ma Guanghui, Zhang Songping*: Separation of bio-particles by ion-exchange chromatography. In: Nesterenko PN, Poole CF, Sun Y (Eds.): Handbooks of Separation Science: Ion-Exchange Chromatography and Related Techniques, 2024, Elsevier, Amsterdam, Netherlands, pp 553-578. (Book Chapter)

2. Feng Xue, Su Zhiguo, Cheng Yuan, Ma Guanghui, Zhang Songping*. Messenger RNA chromatographic purification: advances and challenges. J Chromatography A, 2023, 1707: 464321 (Invited Review)

3. Che Shiyi, Feng Xue, Li Zhengjun, Su Zhiguo, Ma Guanghui, Li Zhikao, Yu Aibing, Liu Minsu*, Zhang Songping*. On-column capping of poly dT media-tethered mRNA accomplishes high capping efficiency, enhanced mRNA recovery, and improved stability against RNase. Biotechnol Bioeng. 2023, doi: 10.1002/bit.28560

4. Luo Hong, Ma Yanyan, Ren Ying, Li Zhengjun, Sheng Yanan, Wang Yingli, SuZ higuo, Bi Jingxiu*, Zhang Songping*. Study of self-assembling properties of HBc-VLP derivatives aided by molecular dynamic simulations from a thermodynamic perspective, Journal of Biomolecular Structure & Dynamics, 2023, DOI: 10.1080/07391102.2023.2273438

5. Li Zhenjun, Ma Yanyan, Ren Ying, Lin Xuan, Su Zhiguo, Zhang Songping*. Thermal-triggered loading and GSH-responsive releasing property of HBc particles for drug delivery. Journal of Controlled Release. 2023, 362:784-796

6. Lin Xuan, Sheng Yanan, Zhang Xuan, Li Zhengjun, Yang Yanli, Wu Jie, Su Zhiguo, Ma Guanghui, Zhang Songping*. Oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine. Journal of Controlled Release,2022, 346:380–391.

7. Lu Fengying, Li Zhegnjun, Sheng Yanan, Ma Yanyan, Yang Yanli, Ren Ying, Su Zhiguo, Yu Rong*, Zhang Songping*. Thermal-triggered packing of lipophilic NIR dye IR780 in hepatitis B core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy. Biomaterials, 2021, 276: 121035

8. Lin Xuan, Yang Yanli, Song Yanmin, Li Shuai, Zhang Xuan, Su Zhiguo*, Zhang Songping*. A possible action of divalent transition metal ions at the interpentameric interface of inactivated foot-and-mouth disease virus provides a simple but effective approach to enhance Stability. Journal of Virology, 2021, 95: e02431-20

9. Song Yanmin, Yang Yanli*, Lin Xuan, Zhao Qizu, Li Zhengjun, Ma Guanghui, Su Zhiguo, Zhang Songping*. On-line separation and quantification of virus antigens of different serotypes in multivalent vaccines by capillary zone electrophoresis: A case study for quality control of foot-and-mouth disease virus vaccines. J Chromatography A. 2021, 1637: 461834

10. Wei Jiangxue, Li Zhengjun, Yang Yanli, Ma Guanghui, Su Zhiguo*, Zhang Songping*. An apoferritin-haemagglutinin conjugate vaccine with encapsulated nucleoprotein antigen peptide from influenza virus confers enhanced cross protection. Bioconjugate Chemistry, 2020, 31: 1948-1959