- 学历/学位: 工学博士学位
- 研究方向:
微生物材料
- 邮箱: dwzheng@ipe.ac.cn
- 地址: 北京市海淀区中关村北二街1号
- 邮编: 100190
- 课题组网站:
简历介绍
郑迪威，中国科学院过程工程研究所项目研究员、博士生导师，生物药制备与递送重点实验室主任助理，入选国家基金委优青（2024）、湖北省高层次人才计划（2023）、过程杰青（2023）。2016年于湖北大学获学士学位，2021年于武汉大学获博士学位，同年任武汉大学化学与分子科学学院特聘副研究员，2023年6月加入中国科学院过程工程研究所。研究领域主要聚焦于微生物材料，重点基于细菌、真菌、病毒等微生物，揭示其在疾病发生、发展和治疗中的作用，基于多学科交叉方法开展理性设计，制备微生物材料，应用于恶性肿瘤、消化道疾病、疫苗等领域。
目前，以一作/通讯作者在Nature Biomedical Engineering (3), Nature Communications (3), Advanced Materials (6)等期刊上发表SCI论文27篇，含ESI高被引论文5篇，被引超6000次。研究成果被美国The Scientist杂志评为“细菌肿瘤疗法的四大代表性成果之一”，也入选中国肠道菌群研究十大成果。担任Aggregate、Smart Mater. Med.、Exploration等多个期刊的编委和青年编委。连续四年入选斯坦福大学发布全球前2%顶尖科学家榜单。曾获第十届中国青少年科技创新奖、中国化学会化学化工与材料京博优秀博士论文奖铜奖、中国生物物理学会纳米生物学分会“优秀青年学者奖”、湖北省“长江学子”、武汉大学十大杰出青年等奖项。
代表论著
1. Zheng, D.-W.#; Deng, W.-W.#; Song, W.-F.; Wu, C.-C.; Liu, J.; Hong, S.; Zhung, Z.-N.; Cheng, H.; Sun, Z.-J. *; Zhang, X.-Z.*,Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma. Nat. Biomed. Eng. 2022, 6, (1), 32-43.
2. Zheng, D.-W.#; Pan, P.#; Chen, K.-W.; Fan, J.-X.; Li, C.-X.; Cheng, H.; Zhang, X.-Z.*, An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure. Nat. Biomed. Eng. 2020,4 (9), 853-862.
3. Zheng, D.-W.#; Dong, X.#; Pan, P.; Chen, K.-W.; Fan, J.-X.; Cheng, S.-X.; Zhang, X.-Z.*, Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy. Nat. Biomed. Eng. 2019,3 (9), 717-728.
4. Zheng, D.-W.#; Gao, F.#; Cheng, Q.; Bao, P.; Dong, X.; Fan, J.-X.; Song, W.; Zeng, X.; Cheng, S.-X.; Zhang, X.-Z.*, A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy. Nat. Commun. 2020,11, 1985.
5. Zheng, D.-W.#; Hong, S.#; Zhang, Q.-L.; Dong, X.; Pan, P.; Song, W.-F.; Song, W.; Cheng, S.-X.; Zhang, X.-Z.*, Controllable gelation of artificial extracellular matrix for altering mass transport and improving cancer therapies. Nat. Commun. 2020,11, 4907.
6. Zheng, D.-W.#; Chen, Y.#; Li, Z.-H.; Xu, L.; Li, C.-X.; Li, B.; Fan, J.-X.; Cheng, S.-X.; Zhang, X.-Z.*, Optically-controlled bacterial metabolite for cancer therapy. Nat. Commun. 2018,9, 1680.
7. Zheng, D.-W.#; Qiao, J.-Y.#; Ma, J.-C.; An, J.-X.; Yang, C.-H.; Zhang, Y.; Cheng, Q.; Rao, Z.-Y.; Zeng, S.-M.; Wang, L.; Zhang, X.-Z.*, A microbial community cultured in gradient hydrogel for investigating gut microbiome-drug interaction and guiding therapeutic decisions. Adv. Mater.2023, 35, 202300977.
8. Zheng, D.-W.#; Chen, K.-W.#; Yan, J.-H.; Rao, Z.-Y.; Yang, C.-H.; Li, R.-L.; Tang, Y.; Cheng, H.; Zhang. X.-Z*. A seed-like hydrogel with metabolic cascade microbiota for oral treatment of liver failure. Mater. Today, 2022, 58, 30-40.
9. Zheng, D.-W.#; Li, R.-Q.#; An, J.-X.; Xie, T.-Q.; Han, Z.-Y.; Xu, R.; Fang, Y.; Zhang, X.-Z.*, Prebiotics-encapsulated probiotic spores regulate gut microbiota and suppress colon cancer. Adv. Mater. 2020,32 (45), 2004529.
10. Zheng, D.-W.#; Xu, L.#; Li, C.-X.; Dong, X.; Pan, P.; Zhang, Q.-L.; Li, B.; Zeng, X.; Zhang, X.-Z.*, Photo-powered artificial organelles for atp generation and life-sustainment. Adv. Mater. 2018,30 (52), 1805038.