夏宇飞
  • 学历/学位: 研究生学历/博士学位
  • 研究方向:

    疫苗佐剂及mRNA递送系统

  • 邮箱: yfxia@ipe.ac.cn
  • 地址: 北京市海淀区中关村北二街1号
  • 邮编: 100190
  • 课题组网站:

简历介绍

夏宇飞博士,国家基金委优秀青年基金获得者,生物材料与生物剂型研究部副主任,致力于疫苗佐剂与mRNA递送系统研究,实现了流感、新冠、带状疱疹等多种疫苗的黏膜和系统性免疫增效。以第一/通讯作者在Nature MaterialsNature CommunicationsCell BiomaterialsAdvanced Materials等发表SCI文章30余篇,申请专利18项(授权5项, PCT专利 2项)。先后主持国家重点研发计划战略性科技创新合作项目(结题优秀)、国家自然科学基金委员会重大项目(课题主持)、国家自然科学基金委员会青年(B类)基金(结题优秀)、中国科学院基础与交叉前沿科研先导专项(项目主持)、中科院从0到1基础前沿科学研究计划等;入选了北京市科技新星、中科院青年创新促进会、北京市青年人才托举计划等;获得了中国科学院院长特别奖、吴瑞奖学金、首届京博科技奖化学化工与材料京博优秀博士奖-金奖(全国唯一)、中国颗粒学会青年颗粒奖、全球华人化工协会未来化工学者奖、国际疫苗协会优秀奖等,受邀担任Research国际期刊青年编委及Scientific Reports编辑,签署合作开发协议2项,合作开发了我国首项常见病在体基因编辑治疗策略获得IIT临床研究许可。

代表论著

1. Yali Ming, Jinji Wei, Zhaoyi Zhai, Zifeng Meng, Xiaonan Huang, Yuning Hu, Qi Huang, Guanghui Ma, Yufei Xia*, Drilling Dendritic Cell Activation: Engineering Interfacial Mechano-Biochemical Cues for Enhanced Immunotherapy. Cell Biomaterials, 2025, 100281 (Highlight).

2. Weixiang Gao#, Kang An#, Yishan Ma#, Xiao Xu, Ziyue Wang, Junjian Liu, Xiangfei Shan, Yuqi Liu, Wei Chen, Peicheng Wang, Changyang Zhou, Ying Ren*, Xiaonan Huang* and Yufei Xia*, Resolving the mRNA Encapsulation-Release Trade-off via Compensatory Forces in Engineered Ionizable Lipids Advanced Materials 2025, e12235 (Frontierpeace Cover).

3. Yan Zhou#, Weixiang Gao#, Xiaonan Huang#, Yumeng Yan#, Sihua Wu, Xiangfei Shan, Shaoyi Chen, Mantang Qiu, Guanghui Ma, Yufei Xia*,  Engineering lipid nanoparticle-stabilized emulsions for spatiotemporal mRNA delivery and enhanced T cell immunity, Cell Reports Medicine 2026, 7(3):102667.

4. Linyu Zuo, Qirui Guo, Cheng Li, Kecheng Zhang, Yancao Chen, Baiyi Jiang, Zhixing Chen, Yufei Xia*, Long Qian*, Lei Zhang*, Zhi Qi*, Deciphering the molecular mechanisms of FET fusion oncoprotein–DNA hollow co-condensates Nature Communications 2025, 16, 9823.

5. Yujie Luo, Chuanda Zhu, Xuefei Guo, Yunfei Xie, Yu Sun, Dan Lu, Yufei Xia*, Zhiqiang Lin*, Fuping You*, Engineering a Lipid Nanoparticle with Atypical Calcium Crystal Structure for Enhanced IFNβ‐Mediated Immunotherapy. Advanced Materials, 2025, 2419870 (Cover).

6. Yumeng Yan#, Xiaonan Huang#, Lili Yuan#, To Ngai, Guanghui Ma, Yufei Xia*, Dictating the spatial-temporal delivery of molecular adjuvant and antigen for the enhanced vaccination, Biomaterials, 2024, 311, 122697

7.Sihua Wu#, Yan Zhou#, Naoki Asakawa, Mei Wen, Yu Sun, Yali Ming, Tiantian Song, Wansong Chen, Guanghui Ma, Yufei Xia*, Engineering CaP-Pickering emulsion for enhanced mRNA cancer vaccines via dual DC and NK activations. Journal of Controlled Release, 2024, 373: 837-852.

8. Tiantian Song, Yufei Xia*, Yiqun Du, Michael W. Chen, Hong Qing*, Guanghui Ma*, Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery, Advanced Materials, 2021, 33(26), 2100106. 

9. Sha Peng#, Fengqiang Cao#, Yufei Xia*, Xiaodong Gao, Lianpan Dai, Jinghua Yan, and Guanghui Ma*, Particulate alum via Pickering emulsion for the enhanced covid-19 vaccine adjuvant, Advanced Materials, 2020, 32(40), 2004210 (Back Cover)

10. Yufei Xia#, Jie Wu#, Wei Wei, Yiqun Du, Tao Wan, Xiaowei Ma, Wenqi An, Aiying Guo, Chunyu Miao, Hua Yue, Shuoguo Li, Xuetao Cao, Zhiguo Su*, Guanghui Ma*, Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination, Nature Materials, 2018, 17(2): 187-194