夏宇飞
  • 学历/学位: 研究生学历/博士学位
  • 研究方向: 疫苗佐剂及递送系统
  • 邮箱: yfxia@ipe.ac.cn
  • 地址: 北京市海淀区中关村北二街1号
  • 邮编: 100190
  • 课题组网站:

简历介绍

夏宇飞博士，中国科学院过程工程研究所项目研究员。致力于基于临床批准材料的疫苗佐剂与核酸递送系统研究。基于创新的颗粒化乳液，先后阐明了柔性、表面结构和组装策略对佐剂生物效应的影响，一定程度上解决了疫苗在淋巴结富集和胞内“按需”释放等递送难题。以第一/通讯作者在Nature Materials、Advanced Materials、ACS Nano等发表SCI文章12篇（6篇入选封面文章），申请专利6项（授权4项，其中1项日本专利）。先后主持国自然基金优秀青年项目、国家重点研发计划战略性科技创新合作项目、中科院从0到1基础前沿科学研究计划等, 受邀参加并获得mRNA疫苗递送的揭榜挂帅重大专项以及中科院优秀青年创新团队的资助；入选了北京市科技新星、中科院青年创新促进会、北京市青年人才托举计划（免疫学会）等；获得了中国科学院院长特别奖、吴瑞奖学金、中国化工学会/京博优秀博士论文金奖（全国唯一）、全球华人化工协会未来化工学者奖、中国颗粒学会青年颗粒奖等，以主要完成人获得中国化工学会科学技术奖基础研究成果奖一等奖以及中国颗粒学会自然科学奖一等奖等。

代表论著

1. Yufei Xia#, Jie Wu#, Wei Wei, Yiqun Du, Tao Wan, Xiaowei Ma, Wenqi An, Aiying Guo, Chunyu Miao, Hua Yue, Shuoguo Li, Xuetao Cao, Zhiguo Su*, Guanghui Ma*, Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination, Nature Materials, 2018, 17(2): 187-194  

2. Yufei Xia#, Jie Wu#, Yiqun Du, Chunyu Miao, Zhiguo Su*, Guanghui Ma*, Bridging systemic immunity with gastrointestinal immune responses via oil-in-polymer capsules, Advanced Materials, 2018, 30(31): 1801067 (Inside Cover) 

3. Yufei Xia#, Xiangming Na#, Jie Wu, Guanghui Ma*, The horizon of the emulsion particulate strategy: engineering hollow particles for biomedical applications, Advanced Materials, 2019, 31, 1801159 (Back Cover) 

4. Yiqun Du#, Yufei Xia#, Yongjuan Zou, Yuning Hu, Jiaqi Fu, Jie Wu*, Xiao-Dong Gao*, Guanghui Ma*, Exploiting the lymph-node-amplifying effect for potent systemic and gastrointestinal immune responses via polymer/lipid nanoparticles, ACS Nano, 2019, 13(12): 13809-13817 (Cover)  18.027

5. Sha Peng#, Fengqiang Cao#, Yufei Xia,* Xiaodong Gao, Lianpan Dai, Jinghua Yan, and Guanghui Ma*, Particulate alum via Pickering emulsion for the enhanced covid-19 vaccine adjuvant, Advanced Materials, 2020, 32, 2004210 (Back Cover) 32.086

6. Yufei Xia#, Tiantian Song#, Guanghui Ma*, Synthetic particles for cancer vaccines: Connecting the inherent supply chain, Accounts of Chemical Research, 2020, 53, 10, 2068–2080 (Cover) 24.466

7. Tiantian Song, Yufei Xia*, Yiqun Du, Michael W. Chen, Hong Qing*, Guanghui Ma*, Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery, Advanced Materials, 2021, 33, 2100106. 32.086

8. Yiqun Du#, Tiantian Song#, Jie Wu, Xiaodong Gao, Guanghui Ma, Yuchen Liu*, Yufei Xia*, Engineering mannosylated Pickering emulsions for the targeted delivery of multicomponent vaccines, Biomaterials, 2022, 280, 121313. 15.304

9. Sihua Wu#, Yufei Xia#, Yuning Hu, Guanghui Ma*, Bio-mimic particles for the enhanced vaccinations: Lessons learnt from the natural traits and pathogenic invasion, Advanced Drug Delivery Reviews, 2021, 113871 17.873

10. Fengqiang Cao#, Sha Peng#, Yaling An#, Kun Xu, Tianyi Zheng, Lianpan Dai, Kenji Ogino, To Ngai, Yufei Xia*, Guanghui Ma*, Inside-out assembly of viral antigens for the enhanced vaccination, Signal Transduction and Targeted Therapy, 2023, 8, 189 IF = 38.12